RHiNO Publications

Physical and sedentary behaviour in pre-term 7 year old children
Kotecha SJ, Lowe J, Richards L, Watkins WJ, Kotecha S. PLoS one. 2016 May 11; 11(5): e0155229

Previous research has found that pre-term born children have shown decrements in lung function, exercise capacity, and increased respiratory symptoms compared to term-born children. This  research paper investigates if  7 year old children born prematurely have decreased levels of physical activity and increased sedentary behaviour as a consequence of increased respiratory problems compared to term born children.


Management of prematurity-associated wheeze and it’s association with Atopy
Edwards MO, Kotecha SJ, Lowe J, Richards L, Watkins WJ, Kotecha S.
PLoS One. 2016 May 11;11(5): e01556995

In this paper produced from the Respiratory and Neurological Outcomes of Preterm Birth Study (RANOPS) the results found that it is common for children born preterm to have increased wheezing problems and more frequently on inhaler treatment than term born children.


Early-term birth is a risk factor for wheezing in childhood: A cross-sectional population study

Edwards MO, Kotecha SJ, Lowe J, Richards L, Watkins WJ, Kotecha S.
J Allergy Clin Immunol. 2015 Sep;136(3):581-587

This research paper was the first one produced from the Respiratory and Neurological Outcomes of Preterm Birth Study (RANOPS). The results show that even being born slightly earlier than normal (around 37-38 weeks) carries some increased risk of respiratory problems in childhood (such as wheezing) compared to birth at 39 weeks or over.


Effect of bronchodilators on forced expiratory volume in 1s in preterm-born participants aged 5 and over: a systematic review
Kotecha SJ, Edwards MO, Watkins WJ, Lowe J, Henderson AJ, Kotecha S.
Neonatology. 2015;107(3):231-4

For this project the research team looked at all the available evidence on whether inhaled medicines (like those used in asthma) help the problems prematurely-born children have with their breathing. Unfortunately, the team found very little research to support if they work (or not). This means that a large study like BEBE may be able to answer this question.


Physical activity in school-age children born preterm
Lowe J, Watkins WJ, Kotecha SJ, Edwards MO, Henderson AJ, Kotecha S.
J Pediatr. 2015 Apr;166(4):877-83

Since we had found that prematurely-born children have lower scores on breathing tests, we wanted to find out if they had reduced levels of physical activity. The results of this study showed that most children actually participate in very similar levels of activity; however, the overall levels in all children were well below the recommended national guidelines.


Higher systolic blood pressure with normal vascular function measurements in preterm-born children
Edwards MO, Watkins WJ, Kotecha SJ, Halcox JP, Dunstan FD, Henderson AJ, Kotecha S.
Acta Paediatr. 2014 Sep;103(9):904-12

In this research paper the team investigated if prematurely born children had any differences in blood pressure compared to children born ‘on time’. A small difference was found which indicated the blood pressure in prematurely born children may be somewhat higher than average.


Effect of preterm birth on later FEV1: a systematic review and meta-analysis
Kotecha SJ, Edwards MO, Watkins WJ, Henderson AJ, Paranjothy S, Dunstan FD, Kotecha S.
Thorax. 2013 Aug;68(8):760-6.

Often one research study is not enough to find out an answer to the question, especially if it is too small. One way to solve this is to look for as many similar studies as possible (a systematic review) and put all the results together (a meta-analysis). By doing this for studies which were all looking at the lung health of children born prematurely, we were able to show that these children have reduced measurements on breathing tests.


Exercise-induced bronchoconstriction in school-aged children who had chronic lung disease in infancy
Joshi S, Powell T, Watkins WJ, Drayton M, Williams EM, Kotecha S.
J Pediatr. 2013 Apr;162(4):813-818

This study showed that children born prematurely can have a narrowing of the airways which happens during exercise. This seemed to be more of a problem for children who needed lots of help for their breathing when they were on the neonatal unit. We found that the narrowing could be improved if a medicine to open the airways was given after exercise. This may help us to understand more about the type of reaction which causes the narrowing to happen.


Long term respiratory outcomes of late preterm-born infants
Kotecha SJ, Dunstan FD, Kotecha S.
Semin Fetal Neonatal Med. 2012 Apr;17(2):77-81

This research paper summarises the current information available on the respiratory health of children and young people who were born prematurely.


Effect of late preterm birth on longitudinal lung spirometry in school age children and adolescents
Kotecha SJ, Watkins WJ, Paranjothy S, Dunstan FD, Henderson AJ, Kotecha S.
Thorax. 2012 Jan;67(1):54-61

This important study showed that children born at 33-34 weeks have lower scores on breathing tests than children born ‘on time’. The scores were similar to children who were born very prematurely (32 weeks or less). These results made us think that this group of children deserve more attention than they have had previously in terms of following them up and seeing how they progress.