{"id":25,"date":"2026-08-23T18:50:52","date_gmt":"2026-08-23T18:50:52","guid":{"rendered":"https:\/\/test.rhino-health.org\/?page_id=25"},"modified":"2026-08-27T13:13:42","modified_gmt":"2026-08-27T13:13:42","slug":"families","status":"publish","type":"page","link":"https:\/\/rhino-health.org\/?page_id=25","title":{"rendered":"Families"},"content":{"rendered":"
\n
\n
\n
\n
Participants & Families<\/div>\n

Thank you for making RHiNO possible<\/h1>\n

\n The original RHiNO study has completed recruitment, but the contribution made by children and
\n families continues to generate new knowledge about respiratory health after preterm birth.\n <\/p>\n

\n See what RHiNO discovered<\/a>
\n The RHiNO study<\/a>\n <\/div>\n<\/p><\/div>\n
\n \"Illustration\n <\/div>\n<\/p><\/div>\n<\/section>\n
\n
\n
\n
A message to our participants<\/div>\n

Every RHiNO discovery began with a family saying yes to research<\/h2>\n

\n Children and families gave their time for questionnaires, home and hospital visits, breathing tests,
\n exercise assessments, treatment studies and specialist lung imaging. Many also provided biological
\n samples and detailed health information.\n <\/p>\n

To all our participants and families: thank you.<\/strong><\/p>\n

\n Although the original study visits finished in November 2019, the information collected through RHiNO
\n continues to support new analyses, publications and longitudinal research.\n <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n

\n
\n
What participation involved<\/div>\n

The RHiNO study was carried out in several stages<\/h2>\n
\n
\n
1<\/div>\n

Questionnaires & screening<\/h3>\n

Families provided information about respiratory symptoms, health and development.<\/p>\n<\/article>\n

\n
2<\/div>\n

Breathing tests<\/h3>\n

Children completed spirometry and bronchodilator testing at home or in a research facility.<\/p>\n<\/article>\n

\n
3<\/div>\n

Detailed lung assessment<\/h3>\n

Some children attended the research facility for more detailed physiological measurements.<\/p>\n<\/article>\n

\n
4<\/div>\n

Exercise & treatment research<\/h3>\n

Selected children completed exercise testing and\/or the randomised inhaler trial.<\/p>\n<\/article>\n

\n
5<\/div>\n

Advanced lung MRI<\/h3>\n

A subgroup travelled to Sheffield for specialist radiation-free hyperpolarised-gas MRI.<\/p>\n<\/article><\/div>\n<\/p><\/div>\n<\/section>\n

\n
\n
\n
What did these visits achieve?<\/div>\n

Participation has contributed to a much broader understanding of lung health<\/h2>\n

\n The RHiNO cohort has supported research into lung function, exercise, inhaled treatment, advanced MRI,
\n air pollution, biological mechanisms and the development of the prematurity-associated lung disease
\n (PLD) phenotype framework.\n <\/p>\n

\n The research is now increasingly asking how lung function and PLD phenotypes change through adolescence
\n and towards adulthood.\n <\/p>\n

\n Explore RHiNO discoveries<\/a>\n <\/div>\n<\/p><\/div>\n
\n \"Illustration\n <\/div>\n<\/p><\/div>\n<\/section>\n
\n
\n
Historical study documents<\/div>\n

Original information for parents, carers and children<\/h2>\n

\n These documents were used while RHiNO was recruiting. They are retained as a historical study archive
\n so participants and researchers can see exactly how the study was explained and conducted.\n <\/p>\n

\n
\n
Part 1<\/div>\n

Screening visit<\/h3>\n

Parent\/carer information and consent, child information and assent, and screening questionnaires for preterm-born and term-born children.<\/p>\n

Open original screening documents \u2197<\/a>
\n <\/article>\n

\n
Part 2<\/div>\n

Detailed assessment & inhaler trial<\/h3>\n

Information and consent\/assent documents for trial participants and preterm-born and term-born control groups.<\/p>\n

Open original trial documents \u2197<\/a>
\n <\/article>\n

\n
Study diaries<\/div>\n

Peak flow, symptoms & inhaler use<\/h3>\n

Historical peak-flow, symptom and inhaler diaries used during different stages of the study.<\/p>\n

Open original diaries \u2197<\/a>
\n <\/article>\n

\n
Part 3<\/div>\n

Sheffield MRI visit<\/h3>\n

Parent and child information and consent\/assent sheets for the advanced lung-imaging component.<\/p>\n

Open original MRI documents \u2197<\/a>
\n <\/article>\n<\/p><\/div>\n

\n Historical archive:<\/strong> these documents describe a study that is no longer recruiting.
\n They should not be interpreted as current invitations to participate.\n <\/div>\n<\/p><\/div>\n<\/section>\n
\n
\n
See what the tests involved<\/div>\n

Videos and explanations from the original study<\/h2>\n

\n The original RHiNO website includes demonstrations of the tests children encountered during the study.\n <\/p>\n

\n
\n

Spirometry & lung-function testing<\/h3>\n

See how breathing tests used in respiratory research are performed.<\/p>\n

View original participant page \u2197<\/a>
\n <\/article>\n

\n

Body box<\/h3>\n

A specialist lung-function test used to measure aspects of lung volume and respiratory physiology.<\/p>\n

View body-box information \u2197<\/a>
\n <\/article>\n

\n

Bicycle exercise test<\/h3>\n

Cardiopulmonary exercise testing helped assess how the lungs and circulation respond during exercise.<\/p>\n

View exercise-test information \u2197<\/a>
\n <\/article>\n

\n

Lung MRI<\/h3>\n

The Sheffield team used a specialist radiation-free MRI technique to examine lung structure and function.<\/p>\n

View MRI information \u2197<\/a>
\n <\/article>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n

\n
\n
What families helped make possible<\/div>\n

From study participation to discoveries that may improve future care<\/h2>\n
\n
PLD<\/strong>A broader framework for respiratory disease after preterm birth.<\/span><\/article>\n
Phenotypes<\/strong>POLD, pPRISm and pDysanapsis reveal different physiological patterns.<\/span><\/article>\n
Treatment<\/strong>The RHiNO inhaler trial demonstrated a treatable component of later lung disease.<\/span><\/article>\n
Lifelong health<\/strong>Longitudinal research is now following how lung function changes as children grow.<\/span><\/article>\n<\/p><\/div>\n
\n Read about the discoveries<\/a>
\n Browse publications<\/a>\n <\/div>\n<\/p><\/div>\n<\/section>\n
\n
\n
Explore RHiNO<\/div>\n
\n
\n

The RHiNO Study<\/h3>\n

How the study developed, what was measured and the full timeline.<\/p>\n

Explore \u2192<\/a><\/article>\n

\n

Our Discoveries<\/h3>\n

What RHiNO has taught us about lung health after preterm birth.<\/p>\n

Explore \u2192<\/a><\/article>\n

\n

PLD & Phenotypes<\/h3>\n

Understand POLD, pPRISm, pDysanapsis and the PLD framework.<\/p>\n

Explore \u2192<\/a><\/article>\n

\n

Research & Publications<\/h3>\n

The complete scientific library generated by the programme.<\/p>\n

Browse \u2192<\/a><\/article>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n

\n
\n
Our preterm lung research programme<\/div>\n

Following respiratory health from birth to later life<\/h2>\n
\n
\n
Birth \u2022 neonatal care<\/div>\n

AZTEC<\/h3>\n

Azithromycin Therapy for Chronic Lung Disease of Prematurity<\/strong><\/p>\n

Visit AZTEC \u2197<\/a>
\n <\/article>\n

\u2192<\/div>\n
\n
Discharge \u2022 infancy<\/div>\n

BALLOON Trial<\/h3>\n

Preventing respiratory infections after discharge<\/strong><\/p>\n

Visit BALLOON \u2197<\/a>
\n <\/article>\n

\u2192<\/div>\n
\n
Childhood \u2022 adolescence \u2022 beyond<\/div>\n

RHiNO<\/h3>\n

Respiratory Health Outcomes in Neonates<\/strong><\/p>\n

RHiNO home \u2192<\/a>
\n <\/article>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Participants & Families Thank you for making RHiNO possible The original RHiNO study has completed recruitment, but the contribution made by children and families continues to generate new knowledge about respiratory health after preterm birth. See what RHiNO discovered The RHiNO study A message to our participants Every RHiNO discovery began with a family saying […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-25","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/pages\/25","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rhino-health.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25"}],"version-history":[{"count":2,"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/pages\/25\/revisions"}],"predecessor-version":[{"id":43,"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/pages\/25\/revisions\/43"}],"wp:attachment":[{"href":"https:\/\/rhino-health.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}