{"id":23,"date":"2026-08-23T18:50:33","date_gmt":"2026-08-23T18:50:33","guid":{"rendered":"https:\/\/test.rhino-health.org\/?page_id=23"},"modified":"2026-08-27T13:13:41","modified_gmt":"2026-08-27T13:13:41","slug":"research-publications","status":"publish","type":"page","link":"https:\/\/rhino-health.org\/?page_id=23","title":{"rendered":"Publications"},"content":{"rendered":"<div class=\"rhino-publications-page\">\n<section class=\"rhino-pub-hero\">\n<div class=\"rhino-pub-wrap rhino-pub-hero-grid\">\n<div>\n<div class=\"rhino-pub-eyebrow\">Research &amp; Publications<\/div>\n<h1>The science generated by RHiNO<\/h1>\n<p class=\"rhino-pub-hero-lead\">\n        RHiNO has developed from population studies of respiratory outcomes after preterm birth into a broad<br \/>\n        research programme spanning PLD phenotypes, treatment, lung physiology, imaging, exercise, environment,<br \/>\n        mechanisms and lifelong respiratory trajectories.\n      <\/p>\n<div class=\"rhino-pub-actions\">\n        <a class=\"rhino-pub-btn\" href=\"https:\/\/rhino-health.org\/pld-phenotypes\/\">PLD &amp; phenotypes<\/a><br \/>\n        <a class=\"rhino-pub-btn rhino-pub-btn-light\" href=\"https:\/\/rhino-health.org\/discoveries\/\">Our discoveries<\/a>\n      <\/div>\n<\/p><\/div>\n<div class=\"rhino-pub-hero-art\">\n      <img decoding=\"async\" src=\"https:\/\/rhino-health.org\/wp-content\/themes\/rhino-research-editable\/assets\/images\/research-collage.png\" alt=\"Illustration representing RHiNO research including lung imaging, inhaled treatment, physiology, environmental exposure and molecular science.\">\n    <\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"rhino-pub-section rhino-pub-feature\">\n<div class=\"rhino-pub-wrap\">\n<div class=\"rhino-pub-eyebrow rhino-pub-eyebrow-light\">Featured<\/div>\n<h2>2026 Lancet Respiratory Medicine PLD Series<\/h2>\n<p class=\"rhino-pub-lead rhino-pub-lead-light\">\n      The three-paper Series synthesises the emerging field of prematurity-associated lung disease across<br \/>\n      the life course: defining PLD and its phenotypes, understanding lifelong lung-function trajectories,<br \/>\n      and considering management from infancy through adulthood.\n    <\/p>\n<div class=\"rhino-pub-series\">\n<article>\n        <span>2026<\/span><\/p>\n<h3>Looking beyond bronchopulmonary dysplasia: prematurity-associated lung disease and its phenotypes<\/h3>\n<p>Defines the PLD framework and describes physiological phenotypes including POLD, pPRISm and pDysanapsis.<\/p>\n<p>        <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41319663\/\" target=\"_blank\" rel=\"noopener\">PubMed \u2197<\/a><br \/>\n      <\/article>\n<article>\n        <span>2026<\/span><\/p>\n<h3>Trajectories of prematurity-associated lung disease: lifelong lung health<\/h3>\n<p>Brings together longitudinal evidence on how respiratory physiology evolves after preterm birth.<\/p>\n<p>        <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41319659\/\" target=\"_blank\" rel=\"noopener\">PubMed \u2197<\/a><br \/>\n      <\/article>\n<article>\n        <span>2026<\/span><\/p>\n<h3>Management of prematurity-associated lung disease from infancy through to adulthood<\/h3>\n<p>Reviews assessment, treatment and prevention strategies across the life course.<\/p>\n<p>        <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41319661\/\" target=\"_blank\" rel=\"noopener\">PubMed \u2197<\/a><br \/>\n      <\/article>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"rhino-pub-section\">\n<div class=\"rhino-pub-wrap\">\n<div class=\"rhino-pub-eyebrow\">Research library<\/div>\n<h2>Browse the complete RHiNO publication programme<\/h2>\n<p class=\"rhino-pub-lead\">\n      Each paper includes a short explanation of why it matters. The library can be searched by title,<br \/>\n      author, journal or topic, and filtered by scientific theme.\n    <\/p>\n<div class=\"rhino-pub-tools\">\n      <label for=\"rhinoPubSearch\"><strong>Search publications<\/strong><\/label><br \/>\n      <input id=\"rhinoPubSearch\" class=\"rhino-pub-search\" type=\"search\"\n             placeholder=\"e.g. POLD, MRI, pollution, exercise, treatment\u2026\"><\/p>\n<div class=\"rhino-pub-filters\">\n        <button type=\"button\" class=\"rhino-pub-filter active\" data-filter=\"all\">All<\/button><br \/>\n        <button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"PLD &amp; phenotypes\">PLD &amp; phenotypes<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Lifelong trajectories\">Lifelong trajectories<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Treatment\">Treatment<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Management\">Management<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Physiology\">Physiology<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Lung function\">Lung function<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Imaging\">Imaging<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Exercise\">Exercise<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Environment\">Environment<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Mechanisms\">Mechanisms<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Early-life determinants\">Early-life determinants<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Cardiovascular\">Cardiovascular<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Biomarkers\">Biomarkers<\/button><button type=\"button\" class=\"rhino-pub-filter\" data-filter=\"Research methods\">Research methods<\/button>\n      <\/div>\n<\/p><\/div>\n<p class=\"rhino-pub-count\"><strong>43 publications and reviews<\/strong> are represented in this library.<\/p>\n<div id=\"rhinoPubGrid\" class=\"rhino-pub-grid\">\n<article class=\"rhino-pub-card\" data-theme=\"Lifelong trajectories\" data-year=\"2026\">\n<div class=\"rhino-pub-meta\"><span>2026<\/span><span>Lifelong trajectories<\/span><\/div>\n<h3>Trajectories of prematurity-associated lung disease: lifelong lung health<\/h3>\n<p class=\"rhino-pub-authors\">Du Berry C, Gray DM, Bates A, et al.<\/p>\n<p class=\"rhino-pub-journal\">Lancet Respiratory Medicine<\/p>\n<p class=\"rhino-pub-summary\">Synthesises evidence on how lung function evolves after preterm birth from childhood into adult life. It highlights heterogeneous trajectories and the need for longitudinal surveillance to identify individuals at risk of persistent obstruction or early COPD.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41319659\/\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Management\" data-year=\"2026\">\n<div class=\"rhino-pub-meta\"><span>2026<\/span><span>Management<\/span><\/div>\n<h3>Management of prematurity-associated lung disease from infancy through to adulthood<\/h3>\n<p class=\"rhino-pub-authors\">Duijts L, Um Bergstr\u00f6m P, Kotecha SJ, Kotecha S, Pijnenburg MW<\/p>\n<p class=\"rhino-pub-journal\">Lancet Respiratory Medicine<\/p>\n<p class=\"rhino-pub-summary\">Reviews management across the life course, from early respiratory symptoms to adult disease. It emphasises phenotype-aware assessment, treatment of reversible components, prevention of additional lung injury and the need for better trial evidence.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41319661\/\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"PLD &amp; phenotypes\" data-year=\"2026\">\n<div class=\"rhino-pub-meta\"><span>2026<\/span><span>PLD &amp; phenotypes<\/span><\/div>\n<h3>Looking beyond bronchopulmonary dysplasia: prematurity-associated lung disease and its phenotypes<\/h3>\n<p class=\"rhino-pub-authors\">Course CW, Bush A, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Lancet Respiratory Medicine<\/p>\n<p class=\"rhino-pub-summary\">Defines PLD as a broader life-course concept than neonatal BPD and describes physiological phenotypes including POLD, pPRISm and pDysanapsis. The paper argues that phenotype-based follow-up may better reflect later respiratory health and support more targeted care.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41319663\/\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Management\" data-year=\"2025\">\n<div class=\"rhino-pub-meta\"><span>2025<\/span><span>Management<\/span><\/div>\n<h3>Recent advances in the management of bronchopulmonary dysplasia<\/h3>\n<p class=\"rhino-pub-authors\">Cosgrove E, Boel L, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Current Treatment Options in Pediatrics<\/p>\n<p class=\"rhino-pub-summary\">Reviews contemporary approaches to BPD prevention and treatment. It places neonatal management in the wider context of improving survival while reducing long-term respiratory morbidity.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Recent%20advances%20in%20the%20management%20of%20bronchopulmonary%20dysplasia%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Exercise\" data-year=\"2025\">\n<div class=\"rhino-pub-meta\"><span>2025<\/span><span>Exercise<\/span><\/div>\n<h3>Physiological responses to exercise in survivors of preterm birth: a meta-analysis<\/h3>\n<p class=\"rhino-pub-authors\">Beaven M, Gibbons J, Course C, Kotecha SJ, Hixson T, Maiorana A, Zuidersma M, Kotecha S, Smith E, Simpson S<\/p>\n<p class=\"rhino-pub-journal\">European Respiratory Review<\/p>\n<p class=\"rhino-pub-summary\">Shows that exercise limitation after preterm birth is not explained by spirometry alone. Across cohorts, abnormalities can involve ventilatory, cardiovascular and metabolic responses, supporting cardiorespiratory fitness as an important life-course outcome.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Physiological%20responses%20to%20exercise%20in%20survivors%20of%20preterm%20birth%3A%20a%20meta-analysis%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Physiology\" data-year=\"2025\">\n<div class=\"rhino-pub-meta\"><span>2025<\/span><span>Physiology<\/span><\/div>\n<h3>Lung volumes, gas transfer and oscillometry after preterm birth: systematic review and meta-analysis<\/h3>\n<p class=\"rhino-pub-authors\">Gibbons JTD, Beaven ML, Course CW, Kotecha SJ, Hixson T, Zuidersma M, Wilson AC, Kotecha S, Simpson SJ<\/p>\n<p class=\"rhino-pub-journal\">European Respiratory Review<\/p>\n<p class=\"rhino-pub-summary\">Systematically evaluates physiological abnormalities beyond standard spirometry after preterm birth. The findings broaden the PLD phenotype by examining lung volumes, gas transfer and oscillometric measures of airway mechanics.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Lung%20volumes%2C%20gas%20transfer%20and%20oscillometry%20after%20preterm%20birth%3A%20systematic%20review%20and%20meta-analysis%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Physiology\" data-year=\"2025\">\n<div class=\"rhino-pub-meta\"><span>2025<\/span><span>Physiology<\/span><\/div>\n<h3>Intra-breath respiratory mechanics of phenotypes of prematurity-associated lung disease in school-aged children<\/h3>\n<p class=\"rhino-pub-authors\">Cousins M, Hart K, Radics B, Henderson AH, Hantos Z, Sly PD, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">ERJ Open Research<\/p>\n<p class=\"rhino-pub-summary\">Uses detailed respiratory mechanics to probe differences between PLD phenotypes beyond conventional spirometry. The study supports the biological distinctness of the physiological groups and helps refine mechanistic phenotyping.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40166049\/\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Lifelong trajectories\" data-year=\"2024\">\n<div class=\"rhino-pub-meta\"><span>2024<\/span><span>Lifelong trajectories<\/span><\/div>\n<h3>Unravelling the respiratory health path across the lifespan for those born too soon<\/h3>\n<p class=\"rhino-pub-authors\">Simpson SJ, Du Berry C, Evans DJ, Gibbons JTD, Volls\u00e6ter M, Halvorsen T, Gruber K, Lombardi E, Stanojevic S, Hurst JR, Um-Bergstr\u00f6m P, Hallberg J, Doyle LW, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Lancet Respiratory Medicine<\/p>\n<p class=\"rhino-pub-summary\">Integrates evidence from childhood through adulthood to show that preterm birth can establish altered respiratory trajectories that persist for decades. The review links developmental lung injury with later chronic respiratory risk.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Unravelling%20the%20respiratory%20health%20path%20across%20the%20lifespan%20for%20those%20born%20too%20soon%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Environment\" data-year=\"2024\">\n<div class=\"rhino-pub-meta\"><span>2024<\/span><span>Environment<\/span><\/div>\n<h3>The impact of ambient air pollution on lung function in preterm-born school-aged children<\/h3>\n<p class=\"rhino-pub-authors\">Watkins WJ, Course CW, Cousins M, Hart K, Kotecha SJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Thorax<\/p>\n<p class=\"rhino-pub-summary\">Examines air pollution as a potentially modifiable exposure in children whose lung development was interrupted by preterm birth. The work supports incorporating post-discharge environmental exposures into models of PLD risk.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22The%20impact%20of%20ambient%20air%20pollution%20on%20lung%20function%20in%20preterm-born%20school-aged%20children%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Mechanisms\" data-year=\"2024\">\n<div class=\"rhino-pub-meta\"><span>2024<\/span><span>Mechanisms<\/span><\/div>\n<h3>Similarities of metabolomic disturbances in prematurity-associated obstructive lung disease to chronic obstructive pulmonary disease<\/h3>\n<p class=\"rhino-pub-authors\">Course CW, Lewis PA, Kotecha SJ, Cousins M, Hart K, Heesom KJ, Watkins WJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Scientific Reports<\/p>\n<p class=\"rhino-pub-summary\">Metabolomic profiling identified disturbances in POLD that overlap with pathways reported in COPD, including oxidative-stress and energy-metabolism pathways. The similarities raise questions about shared mechanisms and future chronic obstructive risk.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39375379\/\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Management\" data-year=\"2024\">\n<div class=\"rhino-pub-meta\"><span>2024<\/span><span>Management<\/span><\/div>\n<h3>Evolving management for prematurity-associated lung disease<\/h3>\n<p class=\"rhino-pub-authors\">Course CW, Kotecha SJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Translational Pediatrics<\/p>\n<p class=\"rhino-pub-summary\">Editorial perspective on how increasing recognition of PLD should change clinical management. It highlights the gap between established asthma pathways and the distinct physiology seen after preterm birth.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Evolving%20management%20for%20prematurity-associated%20lung%20disease%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Management\" data-year=\"2024\">\n<div class=\"rhino-pub-meta\"><span>2024<\/span><span>Management<\/span><\/div>\n<h3>Adherence in paediatric respiratory medicine: a review of the literature<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha EA, Fitzgerald DA, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Paediatric Respiratory Reviews<\/p>\n<p class=\"rhino-pub-summary\">Reviews why adherence is often suboptimal in paediatric respiratory disease and how it can be assessed and improved. The topic is highly relevant when evaluating whether apparent treatment failure reflects biology, delivery or adherence.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Adherence%20in%20paediatric%20respiratory%20medicine%3A%20a%20review%20of%20the%20literature%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Mechanisms\" data-year=\"2023\">\n<div class=\"rhino-pub-meta\"><span>2023<\/span><span>Mechanisms<\/span><\/div>\n<h3>Modulation of pulmonary desmosomes in children with bronchopulmonary dysplasia by inhaler therapy<\/h3>\n<p class=\"rhino-pub-authors\">Course CW, Lewis PA, Kotecha SJ, Cousins M, Hart K, Watkins WJ, Heesom KJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Scientific Reports<\/p>\n<p class=\"rhino-pub-summary\">Investigates epithelial\/desmosomal biology in children with a history of BPD and whether inhaled treatment modifies associated molecular signals. The work links clinical intervention with potential airway structural mechanisms.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Modulation%20of%20pulmonary%20desmosomes%20in%20children%20with%20bronchopulmonary%20dysplasia%20by%20inhaler%20therapy%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Imaging\" data-year=\"2023\">\n<div class=\"rhino-pub-meta\"><span>2023<\/span><span>Imaging<\/span><\/div>\n<h3>Image phenotyping of preterm-born children using hyperpolarised 129Xe lung MRI and multiple-breath washout<\/h3>\n<p class=\"rhino-pub-authors\">Chan HF, Smith LJ, Biancardi AM, Bray J, Marshall H, Hughes PJ, Collier GJ, Rao M, Norquay G, Swift AJ, Hart K, Cousins M, Watkins WJ, Wild JM, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">American Journal of Respiratory and Critical Care Medicine<\/p>\n<p class=\"rhino-pub-summary\">Uses hyperpolarised xenon MRI and multiple-breath washout to reveal regional ventilation and gas-exchange abnormalities after preterm birth. Advanced imaging exposes heterogeneity not fully captured by global spirometry.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Image%20phenotyping%20of%20preterm-born%20children%20using%20hyperpolarised%20129Xe%20lung%20MRI%20and%20multiple-breath%20washout%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Cardiovascular\" data-year=\"2023\">\n<div class=\"rhino-pub-meta\"><span>2023<\/span><span>Cardiovascular<\/span><\/div>\n<h3>Association of gestation and fetal growth restriction on cardiovascular health in preterm-born children<\/h3>\n<p class=\"rhino-pub-authors\">Course CW, Kotecha SJ, Cousins M, Hart K, Lowe J, Watkins WJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Journal of Pediatrics<\/p>\n<p class=\"rhino-pub-summary\">Extends the RHiNO programme beyond the lungs by examining cardiovascular consequences of prematurity and fetal growth restriction. It highlights the shared developmental origins of later cardiopulmonary health.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Association%20of%20gestation%20and%20fetal%20growth%20restriction%20on%20cardiovascular%20health%20in%20preterm-born%20children%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Mechanisms\" data-year=\"2023\">\n<div class=\"rhino-pub-meta\"><span>2023<\/span><span>Mechanisms<\/span><\/div>\n<h3>Association of early and current life factors with telomere length in preterm-born children<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha EA, Zhang L, Aboklaish A, Cousins M, Hart K, Kotecha SJ, Watkins WJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">PLOS ONE<\/p>\n<p class=\"rhino-pub-summary\">Examines telomere length as a potential marker of biological ageing in children born preterm and relates it to early and current exposures. It addresses whether developmental adversity leaves measurable long-term cellular signatures.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Association%20of%20early%20and%20current%20life%20factors%20with%20telomere%20length%20in%20preterm-born%20children%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"PLD &amp; phenotypes\" data-year=\"2022\">\n<div class=\"rhino-pub-meta\"><span>2022<\/span><span>PLD &amp; phenotypes<\/span><\/div>\n<h3>Prematurity-associated lung disease: looking beyond bronchopulmonary dysplasia<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha S, Doull I, Wild J, Bush A<\/p>\n<p class=\"rhino-pub-journal\">Lancet Respiratory Medicine<\/p>\n<p class=\"rhino-pub-summary\">An early conceptual paper arguing that later respiratory disease after preterm birth should not be reduced to a history of BPD. It helped establish the terminology and rationale that subsequently developed into the PLD phenotype framework.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Prematurity-associated%20lung%20disease%3A%20looking%20beyond%20bronchopulmonary%20dysplasia%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Treatment\" data-year=\"2022\">\n<div class=\"rhino-pub-meta\"><span>2022<\/span><span>Treatment<\/span><\/div>\n<h3>Inhaled corticosteroids and long-acting \u03b22 receptor agonists for preterm-born children\u2014new insights but still many questions\u2014reply<\/h3>\n<p class=\"rhino-pub-authors\">Goulden N, Doull I, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">JAMA Pediatrics<\/p>\n<p class=\"rhino-pub-summary\">Author reply discussing interpretation of the RHiNO inhaler trial and the remaining uncertainties. It underscores the need to identify which PLD phenotypes benefit most and how treatment should be translated into practice.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Inhaled%20corticosteroids%20and%20long-acting%20%CE%B22%20receptor%20agonists%20for%20preterm-born%20children%E2%80%94new%20insights%20but%20still%20many%20questions%E2%80%94reply%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Treatment\" data-year=\"2022\">\n<div class=\"rhino-pub-meta\"><span>2022<\/span><span>Treatment<\/span><\/div>\n<h3>Inhaled corticosteroids alone and in combination with long-acting \u03b22 receptor agonists to treat reduced lung function in preterm-born children: a randomized clinical trial<\/h3>\n<p class=\"rhino-pub-authors\">Goulden N, Cousins M, Hart K, Jenkins A, Willet G, Yendle L, Doull I, Williams M, Henderson AJ, Hoare Z, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">JAMA Pediatrics<\/p>\n<p class=\"rhino-pub-summary\">The RHiNO randomised trial demonstrated a clinically important improvement in lung function with combined ICS\/LABA in selected preterm-born children with reduced FEV1. It provides direct evidence that part of PLD is modifiable with inhaled therapy.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Inhaled%20corticosteroids%20alone%20and%20in%20combination%20with%20long-acting%20%CE%B22%20receptor%20agonists%20to%20treat%20reduced%20lung%20function%20in%20preterm-born%20children%3A%20a%20randomized%20clinical%20trial%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Exercise\" data-year=\"2022\">\n<div class=\"rhino-pub-meta\"><span>2022<\/span><span>Exercise<\/span><\/div>\n<h3>Impaired exercise outcomes with significant bronchodilator responsiveness in children with prematurity-associated obstructive lung disease<\/h3>\n<p class=\"rhino-pub-authors\">Cousins M, Hart K, Williams M, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Pediatric Pulmonology<\/p>\n<p class=\"rhino-pub-summary\">Shows impaired exercise performance in children with POLD and examines bronchodilator responsiveness during physiological assessment. The findings connect airflow obstruction with functional limitation and potentially treatable physiology.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Impaired%20exercise%20outcomes%20with%20significant%20bronchodilator%20responsiveness%20in%20children%20with%20prematurity-associated%20obstructive%20lung%20disease%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Lung function\" data-year=\"2022\">\n<div class=\"rhino-pub-meta\"><span>2022<\/span><span>Lung function<\/span><\/div>\n<h3>Geographical differences and temporal improvements in FEV1 of preterm-born children: a systematic review and meta-analysis<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha SJ, Gibbons JTD, Course CW, Evans EE, Simpson SJ, Watkins WJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">JAMA Pediatrics<\/p>\n<p class=\"rhino-pub-summary\">Meta-analysis showing that later FEV1 after preterm birth varies across geography and birth eras. The work suggests respiratory outcomes are influenced not only by gestation but also by changes in neonatal care and population context.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Geographical%20differences%20and%20temporal%20improvements%20in%20FEV1%20of%20preterm-born%20children%3A%20a%20systematic%20review%20and%20meta-analysis%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Early-life determinants\" data-year=\"2022\">\n<div class=\"rhino-pub-meta\"><span>2022<\/span><span>Early-life determinants<\/span><\/div>\n<h3>Association of early life factors and prematurity-associated lung disease: a prospective cohort study<\/h3>\n<p class=\"rhino-pub-authors\">Hart K, Cousins M, Watkins WJ, Kotecha SJ, Henderson AJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">European Respiratory Journal<\/p>\n<p class=\"rhino-pub-summary\">Links neonatal and early-life characteristics with school-age PLD. The analysis shows that later respiratory impairment reflects a combination of developmental and perinatal factors rather than BPD status alone.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Association%20of%20early%20life%20factors%20and%20prematurity-associated%20lung%20disease%3A%20a%20prospective%20cohort%20study%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Biomarkers\" data-year=\"2021\">\n<div class=\"rhino-pub-meta\"><span>2021<\/span><span>Biomarkers<\/span><\/div>\n<h3>Volatile organic compounds as disease biomarkers in newborn infants: a systematic review<\/h3>\n<p class=\"rhino-pub-authors\">Course C, Watkins WJ, Muller CT, Odd D, Kotecha S, Chakraborty M<\/p>\n<p class=\"rhino-pub-journal\">Journal of Breath Research<\/p>\n<p class=\"rhino-pub-summary\">Systematically reviews volatile organic compounds as non-invasive biomarkers in newborn disease. The work explores whether breath-based chemical signatures could support early diagnosis or phenotyping in neonatal medicine.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Volatile%20organic%20compounds%20as%20disease%20biomarkers%20in%20newborn%20infants%3A%20a%20systematic%20review%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Early-life determinants\" data-year=\"2020\">\n<div class=\"rhino-pub-meta\"><span>2020<\/span><span>Early-life determinants<\/span><\/div>\n<h3>The effect of catch-up growth in the first year of life on later wheezing phenotypes<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha SJ, Lowe J, Granell R, Watkins WJ, Henderson AJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">European Respiratory Journal<\/p>\n<p class=\"rhino-pub-summary\">Examines how infant catch-up growth relates to later wheezing patterns. It contributes to the developmental model in which postnatal growth can modify respiratory outcomes after an adverse start to life.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22The%20effect%20of%20catch-up%20growth%20in%20the%20first%20year%20of%20life%20on%20later%20wheezing%20phenotypes%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Physiology\" data-year=\"2019\">\n<div class=\"rhino-pub-meta\"><span>2019<\/span><span>Physiology<\/span><\/div>\n<h3>Fractional exhaled nitric oxide in preterm-born subjects: a systematic review and meta-analysis<\/h3>\n<p class=\"rhino-pub-authors\">Course C, Kotecha S, Kotecha SJ<\/p>\n<p class=\"rhino-pub-journal\">Pediatric Pulmonology<\/p>\n<p class=\"rhino-pub-summary\">Evaluates FeNO after preterm birth to test whether airway inflammation resembles conventional eosinophilic asthma. The findings help distinguish PLD biology from asthma and inform interpretation of inhaled corticosteroid response.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Fractional%20exhaled%20nitric%20oxide%20in%20preterm-born%20subjects%3A%20a%20systematic%20review%20and%20meta-analysis%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Early-life determinants\" data-year=\"2019\">\n<div class=\"rhino-pub-meta\"><span>2019<\/span><span>Early-life determinants<\/span><\/div>\n<h3>Comparison of associations of early life factors on wheezing phenotypes in preterm-born and term-born children<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha SJ, Lowe J, Watkins WJ, Granell R, Henderson AJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">American Journal of Epidemiology<\/p>\n<p class=\"rhino-pub-summary\">Compares determinants of wheezing phenotypes in preterm and term-born children. It demonstrates that apparently similar respiratory symptoms can arise from different developmental backgrounds and risk structures.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Comparison%20of%20associations%20of%20early%20life%20factors%20on%20wheezing%20phenotypes%20in%20preterm-born%20and%20term-born%20children%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Lifelong trajectories\" data-year=\"2018\">\n<div class=\"rhino-pub-meta\"><span>2018<\/span><span>Lifelong trajectories<\/span><\/div>\n<h3>Long-term respiratory outcomes following preterm birth<\/h3>\n<p class=\"rhino-pub-authors\">Cousins M, Hart K, Gallacher D, Palomino MA, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Revista M\u00e9dica Cl\u00ednica Las Condes<\/p>\n<p class=\"rhino-pub-summary\">Reviews the respiratory consequences of preterm birth beyond infancy. It summarises persistent symptoms, lung-function impairment and the emerging concern about future chronic obstructive disease.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Long-term%20respiratory%20outcomes%20following%20preterm%20birth%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Early-life determinants\" data-year=\"2018\">\n<div class=\"rhino-pub-meta\"><span>2018<\/span><span>Early-life determinants<\/span><\/div>\n<h3>Effect of foetal and infant growth and body composition on respiratory outcomes in preterm-born children<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha SJ, Lowe J, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Paediatric Respiratory Reviews<\/p>\n<p class=\"rhino-pub-summary\">Reviews links between fetal growth, infant growth, body composition and later respiratory outcomes. It places lung development within a wider developmental-origins framework.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Effect%20of%20foetal%20and%20infant%20growth%20and%20body%20composition%20on%20respiratory%20outcomes%20in%20preterm-born%20children%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Early-life determinants\" data-year=\"2018\">\n<div class=\"rhino-pub-meta\"><span>2018<\/span><span>Early-life determinants<\/span><\/div>\n<h3>Effect of fetal and infant growth on respiratory symptoms in preterm-born children<\/h3>\n<p class=\"rhino-pub-authors\">Lowe J, Kotecha SJ, Watkins WJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Pediatric Pulmonology<\/p>\n<p class=\"rhino-pub-summary\">Examines fetal and early postnatal growth as determinants of later respiratory symptoms. The study supports the importance of growth restriction and growth trajectories in long-term lung health.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Effect%20of%20fetal%20and%20infant%20growth%20on%20respiratory%20symptoms%20in%20preterm-born%20children%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Early-life determinants\" data-year=\"2018\">\n<div class=\"rhino-pub-meta\"><span>2018<\/span><span>Early-life determinants<\/span><\/div>\n<h3>Does the sex of the preterm baby affect respiratory outcomes?<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha SJ, Lowe J, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Breathe<\/p>\n<p class=\"rhino-pub-summary\">Reviews sex-related differences in respiratory outcomes after preterm birth. It considers whether biological sex modifies vulnerability during lung development and subsequent respiratory morbidity.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Does%20the%20sex%20of%20the%20preterm%20baby%20affect%20respiratory%20outcomes%3F%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Research methods\" data-year=\"2017\">\n<div class=\"rhino-pub-meta\"><span>2017<\/span><span>Research methods<\/span><\/div>\n<h3>Transitioning from clinical to research nursing<\/h3>\n<p class=\"rhino-pub-authors\">Willets G, Yendle L, Kotecha S, Hart K<\/p>\n<p class=\"rhino-pub-journal\">Welsh Paediatric Journal<\/p>\n<p class=\"rhino-pub-summary\">Describes practical and professional aspects of moving from clinical nursing into research delivery. It reflects the multidisciplinary infrastructure required to conduct detailed paediatric cohort and intervention studies.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Transitioning%20from%20clinical%20to%20research%20nursing%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Lifelong trajectories\" data-year=\"2017\">\n<div class=\"rhino-pub-meta\"><span>2017<\/span><span>Lifelong trajectories<\/span><\/div>\n<h3>Respiratory outcomes after preterm birth<\/h3>\n<p class=\"rhino-pub-authors\">Hart K, Cousins M, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Minerva Pulmonology<\/p>\n<p class=\"rhino-pub-summary\">Review of the spectrum of respiratory outcomes after preterm birth, emphasising that morbidity persists beyond the neonatal period and requires long-term clinical and research attention.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Respiratory%20outcomes%20after%20preterm%20birth%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Exercise\" data-year=\"2017\">\n<div class=\"rhino-pub-meta\"><span>2017<\/span><span>Exercise<\/span><\/div>\n<h3>Physical activity outcomes following preterm birth<\/h3>\n<p class=\"rhino-pub-authors\">Lowe J, Cousins M, Kotecha SJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Paediatric Respiratory Reviews<\/p>\n<p class=\"rhino-pub-summary\">Reviews physical activity and exercise outcomes after preterm birth. It broadens assessment beyond lung-function numbers to participation, fitness and everyday functional health.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Physical%20activity%20outcomes%20following%20preterm%20birth%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Exercise\" data-year=\"2016\">\n<div class=\"rhino-pub-meta\"><span>2016<\/span><span>Exercise<\/span><\/div>\n<h3>Physical and sedentary behaviour in pre-term 7-year-old children<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha SJ, Lowe J, Richards L, Watkins WJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">PLOS ONE<\/p>\n<p class=\"rhino-pub-summary\">Measures physical and sedentary behaviour in children born preterm. It asks whether respiratory and developmental consequences of prematurity translate into altered everyday activity.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Physical%20and%20sedentary%20behaviour%20in%20pre-term%207-year-old%20children%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Management\" data-year=\"2016\">\n<div class=\"rhino-pub-meta\"><span>2016<\/span><span>Management<\/span><\/div>\n<h3>Management of prematurity-associated wheeze and its association with atopy<\/h3>\n<p class=\"rhino-pub-authors\">Edwards MO, Kotecha SJ, Lowe J, Richards L, Watkins WJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">PLOS ONE<\/p>\n<p class=\"rhino-pub-summary\">Examines treatment of wheeze after preterm birth and its relationship with atopy. The study questions whether asthma-style treatment is always biologically appropriate for prematurity-associated respiratory symptoms.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Management%20of%20prematurity-associated%20wheeze%20and%20its%20association%20with%20atopy%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Exercise\" data-year=\"2015\">\n<div class=\"rhino-pub-meta\"><span>2015<\/span><span>Exercise<\/span><\/div>\n<h3>Physical activity in school-age children born preterm<\/h3>\n<p class=\"rhino-pub-authors\">Lowe J, Watkins WJ, Kotecha SJ, Edwards MO, Henderson AJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Journal of Pediatrics<\/p>\n<p class=\"rhino-pub-summary\">Assesses physical activity after preterm birth at school age. The study examines whether developmental lung and health differences translate into measurable differences in habitual activity.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Physical%20activity%20in%20school-age%20children%20born%20preterm%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Treatment\" data-year=\"2015\">\n<div class=\"rhino-pub-meta\"><span>2015<\/span><span>Treatment<\/span><\/div>\n<h3>Effect of bronchodilators on FEV1 in preterm-born participants aged 5 and over: a systematic review<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha SJ, Edwards MO, Watkins WJ, Henderson AJ, Paranjothy S, Dunstan FD, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Neonatology<\/p>\n<p class=\"rhino-pub-summary\">Systematically reviews bronchodilator responsiveness after preterm birth. It provides early evidence that a reversible component of airflow limitation exists in at least some preterm-born individuals.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Effect%20of%20bronchodilators%20on%20FEV1%20in%20preterm-born%20participants%20aged%205%20and%20over%3A%20a%20systematic%20review%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Early-life determinants\" data-year=\"2015\">\n<div class=\"rhino-pub-meta\"><span>2015<\/span><span>Early-life determinants<\/span><\/div>\n<h3>Early-term birth is a risk factor for wheezing in childhood: a cross-sectional population study<\/h3>\n<p class=\"rhino-pub-authors\">Edwards MO, Kotecha SJ, Lowe J, Richards L, Watkins WJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Journal of Allergy and Clinical Immunology<\/p>\n<p class=\"rhino-pub-summary\">Shows that respiratory risk is not confined to very preterm birth, with early-term birth also associated with later wheeze. This supports a gestational-age continuum of respiratory vulnerability.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Early-term%20birth%20is%20a%20risk%20factor%20for%20wheezing%20in%20childhood%3A%20a%20cross-sectional%20population%20study%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Cardiovascular\" data-year=\"2014\">\n<div class=\"rhino-pub-meta\"><span>2014<\/span><span>Cardiovascular<\/span><\/div>\n<h3>Higher systolic blood pressure with normal vascular function measurements in preterm-born children<\/h3>\n<p class=\"rhino-pub-authors\">Edwards MO, Watkins WJ, Kotecha SJ, Halcox JP, Dunstan FD, Henderson AJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Acta Paediatrica<\/p>\n<p class=\"rhino-pub-summary\">Identifies higher systolic blood pressure in preterm-born children despite otherwise normal vascular measures. It adds to evidence that prematurity has multisystem cardiovascular as well as respiratory consequences.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Higher%20systolic%20blood%20pressure%20with%20normal%20vascular%20function%20measurements%20in%20preterm-born%20children%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Exercise\" data-year=\"2013\">\n<div class=\"rhino-pub-meta\"><span>2013<\/span><span>Exercise<\/span><\/div>\n<h3>Exercise-induced bronchoconstriction in school-aged children who had chronic lung disease in infancy<\/h3>\n<p class=\"rhino-pub-authors\">Joshi S, Powell T, Watkins WJ, Drayton M, Williams EM, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Journal of Pediatrics<\/p>\n<p class=\"rhino-pub-summary\">Examines exercise-induced bronchoconstriction in children with neonatal chronic lung disease. It explores whether exertional symptoms reflect reversible airway narrowing and how this differs from conventional asthma.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Exercise-induced%20bronchoconstriction%20in%20school-aged%20children%20who%20had%20chronic%20lung%20disease%20in%20infancy%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Lung function\" data-year=\"2013\">\n<div class=\"rhino-pub-meta\"><span>2013<\/span><span>Lung function<\/span><\/div>\n<h3>Effect of preterm birth on later FEV1: a systematic review and meta-analysis<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha SJ, Edwards MO, Watkins WJ, Henderson AJ, Paranjothy S, Dunstan FD, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Thorax<\/p>\n<p class=\"rhino-pub-summary\">A foundational meta-analysis showing persistent reduction in expiratory airflow after preterm birth. It helped establish impaired later lung function as a major long-term consequence of prematurity.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Effect%20of%20preterm%20birth%20on%20later%20FEV1%3A%20a%20systematic%20review%20and%20meta-analysis%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Lifelong trajectories\" data-year=\"2012\">\n<div class=\"rhino-pub-meta\"><span>2012<\/span><span>Lifelong trajectories<\/span><\/div>\n<h3>Long-term respiratory outcomes of late preterm-born infants<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha SJ, Dunstan FD, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Seminars in Fetal and Neonatal Medicine<\/p>\n<p class=\"rhino-pub-summary\">Reviews evidence that late-preterm birth, despite being relatively close to term, can still have lasting respiratory consequences. It reinforces the concept of respiratory risk across the gestational-age spectrum.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Long-term%20respiratory%20outcomes%20of%20late%20preterm-born%20infants%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<article class=\"rhino-pub-card\" data-theme=\"Lung function\" data-year=\"2012\">\n<div class=\"rhino-pub-meta\"><span>2012<\/span><span>Lung function<\/span><\/div>\n<h3>Effect of late preterm birth on longitudinal lung spirometry in school age children and adolescents<\/h3>\n<p class=\"rhino-pub-authors\">Kotecha SJ, Watkins WJ, Paranjothy S, Dunstan FD, Henderson AJ, Kotecha S<\/p>\n<p class=\"rhino-pub-journal\">Thorax<\/p>\n<p class=\"rhino-pub-summary\">Longitudinally examines spirometry after late-preterm birth through school age and adolescence. The study demonstrates that modestly shortened gestation can influence lung-function development well beyond infancy.<\/p>\n<p>  <a class=\"rhino-pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Effect%20of%20late%20preterm%20birth%20on%20longitudinal%20lung%20spirometry%20in%20school%20age%20children%20and%20adolescents%22%5BTitle%5D\" target=\"_blank\" rel=\"noopener\">PubMed \/ source \u2197<\/a><br \/>\n<\/article>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"rhino-pub-section rhino-pub-pale\">\n<div class=\"rhino-pub-wrap\">\n<div class=\"rhino-pub-eyebrow\">How the science fits together<\/div>\n<h2>From population observation to mechanism and intervention<\/h2>\n<div class=\"rhino-pub-theme-grid\">\n<article>\n<h3>Describe<\/h3>\n<p>Population studies establish the long-term respiratory consequences of preterm birth.<\/p>\n<\/article>\n<article>\n<h3>Phenotype<\/h3>\n<p>Detailed lung physiology identifies POLD, pPRISm, pDysanapsis and other measurable abnormalities.<\/p>\n<\/article>\n<article>\n<h3>Explain<\/h3>\n<p>Imaging, metabolomics, mechanics and environmental studies investigate why those phenotypes occur.<\/p>\n<\/article>\n<article>\n<h3>Treat<\/h3>\n<p>Randomised and bronchodilator studies test whether abnormal physiology can be modified.<\/p>\n<\/article>\n<article>\n<h3>Follow<\/h3>\n<p>Longitudinal research asks how childhood phenotype influences later respiratory health.<\/p>\n<\/article><\/div>\n<\/p><\/div>\n<\/section>\n<section class=\"rhino-pub-section rhino-pub-sky\">\n<div class=\"rhino-pub-wrap\">\n<div class=\"rhino-pub-eyebrow\">Explore RHiNO<\/div>\n<div class=\"rhino-pub-links-grid\">\n<article>\n<h3>Our Discoveries<\/h3>\n<p>The major findings explained in accessible language.<\/p>\n<p><a href=\"https:\/\/rhino-health.org\/discoveries\/\">Explore \u2192<\/a><\/article>\n<article>\n<h3>PLD &amp; Phenotypes<\/h3>\n<p>The physiological framework behind POLD, pPRISm and pDysanapsis.<\/p>\n<p><a href=\"https:\/\/rhino-health.org\/pld-phenotypes\/\">Explore \u2192<\/a><\/article>\n<article>\n<h3>The RHiNO Study<\/h3>\n<p>How the cohort was recruited, assessed and followed.<\/p>\n<p><a href=\"https:\/\/rhino-health.org\/rhino-study\/\">Explore \u2192<\/a><\/article>\n<article>\n<h3>Participants &amp; Families<\/h3>\n<p>The people who made the RHiNO research programme possible.<\/p>\n<p><a href=\"https:\/\/rhino-health.org\/families\/\">Explore \u2192<\/a><\/article>\n<\/p><\/div>\n<\/p><\/div>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research &amp; Publications The science generated by RHiNO RHiNO has developed from population studies of respiratory outcomes after preterm birth into a broad research programme spanning PLD phenotypes, treatment, lung physiology, imaging, exercise, environment, mechanisms and lifelong respiratory trajectories. PLD &amp; phenotypes Our discoveries Featured 2026 Lancet Respiratory Medicine PLD Series The three-paper Series synthesises [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-23","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/pages\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rhino-health.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23"}],"version-history":[{"count":2,"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/pages\/23\/revisions"}],"predecessor-version":[{"id":42,"href":"https:\/\/rhino-health.org\/index.php?rest_route=\/wp\/v2\/pages\/23\/revisions\/42"}],"wp:attachment":[{"href":"https:\/\/rhino-health.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}